Urea is an organic chemical substance that is probably most familiar because of its purpose within a fertilizer made use of in farming. Urea takes on a crucial part within our bodies metabolic process and is an important procedure by which your body gets rid of additional nitrogen. It is manufactured within the liver from an ammonia compound using the deamination of aminos as being the principal end product of proteins catabolism. It includes two amine groups that are attached together by way of a carbonyl chemical group. In 1928 Friedrich Wöhler proved the first time that an organic compound can be produced from inorganic compounds as he had been able to synthetise urea from its inorganic components in the lab. The synthesised form of the urea is very popular as a topical cream or applied treatment useful to care for numerous skin complaints. It is now so essential because of this that urea is currently listed by the WHO with their List of Essential Drugs that it suggests that all nations gain access to. In skin which is dry, it has been shown that there's a considerable reduction in urea within the epidermis, therefore hence the need to use the urea products. These types of skin complaints include simple skin conditions such as dry skin or the more severe skin conditions including psoriasis, eczema along with ichthyosis. These ointments are often times employed by podiatrists following the debridement of cracked skin around the heels.

Urea treatments have different affects on various skin complaints dependant upon their concentration in the lotion. At amounts close to 40% the urea will dissolve the cellular matrix of the nail plate therefore can be used to take care of toe nail dystrophy problems by dissolving part of the toenail. This could be useful for disorders such as mycotic infections of the nails. At levels less than that, yet still above 20% the urea cream is known as a keratolytic which implies it can cause a breakdown of proteins in the skin, and so the dry skin may well flake off, particularly with the cracked dried-out skin around the heel of the foot. At amounts of below about 20% the urea lotion behaves as a humectant that means it helps your skin keep moisture and lower water loss and make the epidermis soft along with supple. Urea has an additional benefit because it also has anti-pruritic affects which means that it can help with the dryer skin complaints that are additionally itching. There are not really any adverse reactions making use of these urea creams on the epidermis except for an infrequent local irritability that just about usually clears up once you end using the product. In contrast to a great deal of other drugs, there aren't any identified interactions between urea and some other drugs which might be used. Urea really should not used when there is a recognized hypersensitivity to it or many of the additional ingredients which are utilized in making the product. You will find literally hundred's of different brands of urea creams including the Walkers Urea 15  Foot Cream from Australia as well as Keralac Cream from the United States. At all times steer clear of exposure to the eyes using the urea cream and also clean the hands after making use of it.